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Immobilized Human LDL R, Strep Tag at 10 ug/mL (100 uL/well) can bind Rhesus macaque PCSK9, His Tag with a linear range of 2-15 ng/mL.
Immobilized Human LDL R, Strep Tag at 10 ug/mL (100 uL/well) can bind Rhesus macaque PCSK9, His Tag with a linear range of 2-15 ng/mL.

PCSK9 Recombinant Protein

CATALOG NUMBER: 97-068

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Rhesus monkey
source-species:
HEK293 cells
Recombinant Protein Sequence:
Gln 31 - Gln 692
Fusion Tag:
His Tag
Tested Applications:
ELISA, WB
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Predicted Molecular Weight:
73.2 kDa
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human LDL R, Strep Tag at 10 ug/mL (100 uL/well) can bind Rhesus macaque PCSK9, His Tag with a linear range of 2-15 ng/mL.
Purity:
>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
PCSK9
Additional Names:
PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9
Protein Accession Number:
A8T666
Ncbi Gene Id Number:
717147
Background:
Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene.This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
Background Reference 1:
Seidah NG, et al., Proc. Natl. Acad. Sci. U.S.A. 100 (3): 928–33.
Background Reference 2:
Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.
Background Reference 3:
Dubuc G. et al., 2004, Arterioscler. Thromb. Vasc. Biol. 24 (8): 1454–9.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

97-068

List Size:
0.05 mg

List Price:

$495.00

Datasheet
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