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Western blot analysis of extracts from HepG2 tissue using Phospho-PDCD4 (Ser67) Antibody. The lane on the right is treated with the antigen-specific peptide.
Western blot analysis of extracts from HepG2 tissue using Phospho-PDCD4 (Ser67) Antibody. The lane on the right is treated with the antigen-specific peptide.

PDCD4 (phospho Ser67) Antibody

CATALOG NUMBER: 79-977

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
PDCD4 (phospho Ser67) antibody was raised against a peptide sequence around phosphorylation site of serine 67 (K-N-S (p)-S-R) derived from Human PDCD4 .
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:500~1:1000
Specificity:
The antibody detects endogenous level of PDCD4 only when phosphorylated at serine 67.
Predicted Molecular Weight:
56 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
PDCD4
Additional Names:
neoplastic transformation inhibitor
Protein Accession Number:
NP_001186421.1
Protein Gi Number:
21735598
Ncbi Gene Id Number:
27250
Background:
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA
Background Reference 1:
Kakade D, Islam N, Maeda N, Adegoke OA (2014)BMC Cell Biol 15, 2 . Dorrello NV, et al. (2006)Science 314, 467-71. Palamarchuk A, et al. (2005)Cancer Res 65, 11282-6.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-977

List Size:
0.1 mg

List Price:

$355.00

Out of stock

Datasheet
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