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Western blot analysis of PDCL2 in rat liver tissue lysate with PDCL2 antibody at 1 μg/ml.
Western blot analysis of PDCL2 in rat liver tissue lysate with PDCL2 antibody at 1 μg/ml.
Trial Size

PDCL2 Antibody

CATALOG NUMBER: 7887

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
PDCL2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human PDCL2.
The immunogen is located within the last 50 amino acids of PDCL2.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
PDCL2 antibody can be used for detection of PDCL2 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Specificity:
PDCL2 antibody is human, mouse and rat reactive. PDCL2 antibody is predicted to not cross-react with other members of the PDCL protein family.
Positive Control 1:
Cat. No. 1464 - Rat Liver Tissue Lysate
Predicted Molecular Weight:
Predicted: 27 kDa
Observed: 25 kDa
Purification:
PDCL2 antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
PDCL2 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
PDCL2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
PDCL2
Additional Names:
PDCL2 Antibody: GCPHLP, Phosducin-like protein 2
Protein Accession Number:
NP_689614
Protein Gi Number:
51944950
Ncbi Gene Id Number:
132954
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains that were initially identified as modulators of G protein signaling (1,2). PDCL2 is highly homologous to PDCL and shares an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain (3). PDCL2 has been shown to interact with the chaperonin CCT and is essential for cytoskeletal protein function and cell cycle progression (4).
Background Reference 1:
Miles MF, Barhite S, Sganga M, et al. Phosducin-like protein: an ethanol-responsive potential modulator of guanine nucleotide-binding protein function. Proc. Natl. Acad. Sci. USA 1993; 90:10831-5.
Background Reference 2:
Ruiz-Gomez A, Humrich J, Murga C, et al. Phosphorylation of phosducin and phosducinlike protein by G protein-coupled receptor kinase 2. J. Biol. Chem. 2000; 275:29724-30.
Background Reference 3:
Lou X, Bao R, Zhou CZ, et al. Structure of the thioredoxin-fold domain of human phosducin-like protein 2. Acta Crystallographica 2009; F65:67-70.
Background Reference 4:
Stirling PC, Srayko M, Takhar KS, et al. Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeltal protein function and cell cycle progrssion. Mol. Biol. Cell 2007; 18:2336-45.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7887

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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