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Antibody used in WB on Human OVCAR-3 at 0.2-1 ug/ml.
Antibody used in WB on Human OVCAR-3 at 0.2-1 ug/ml.

PDE Antibody

CATALOG NUMBER: 31-306

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PDE.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
PDE antibody can be used for detection of PDE by ELISA at 1:1562500. PDE antibody can be used for detection of PDE by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Positive Control 1:
OVCAR-3 Cell Lysate
Predicted Molecular Weight:
67 kDa
Purification:
Antibody is purified by peptide affinity chromatography method.
Clonality:
Polyclonal
Physical State:
Liquid
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Storage Conditions:
For short periods of storage (days) store at 4°C. For longer periods of storage, store PDE antibody at -20°C. As with any antibody avoid repeat freeze-thaw cycles.
Ncbi Official Symbol:
PDE12
Additional Names:
2'-PDE, 2'-PDE
Protein Accession Number:
NP_808881
Protein Gi Number:
189027129
Ncbi Gene Id Number:
201626
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
2'-PDE is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. 2'-PDE also cleaves 3',5'-phosphodiester bond of oligoadenylates. 2'-PDE play a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.
Background Reference 1:
Kubota, K., (2004) J. Biol. Chem. 279 (36), 37832-37841 .

FOR RESEARCH USE ONLY

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Disclaimer:
This product is for research use only.

CATALOG NUMBER:

31-306

List Size:
100 ul

List Price:

$519.00

Datasheet
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