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Western blot analysis in mouse stomach tissue lysates (35ug/lane).
PDE11A Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human colon tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in mouse stomach tissue lysates (35ug/lane).

PDE11A Antibody

CATALOG NUMBER: 57-410

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
This PDE11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-63 amino acids from the N-terminal region of human PDE11A.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
105 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PDE11A
Additional Names:
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cGMP phosphodiesterase 11A, PDE11A
Protein Accession Number:
Q9HCR9
Protein Gi Number:
296439264
Ncbi Gene Id Number:
50940
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The 3',5'-cyclic nucleotides cAMP and cGMP function assecond messengers in a wide variety of signal transductionpathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs)catalyze the hydrolysis of cAMP and cGMP to the corresponding5'-monophosphates and provide a mechanism to downregulate cAMP andcGMP signaling. This gene encodes a member of the PDE proteinsuperfamily. Mutations in this gene are a cause of Cushing diseaseand adrenocortical hyperplasia. Multiple transcript variantsencoding different isoforms have been found for this gene.
Background Reference 1:
DeWan, A.T., et al. J. Allergy Clin. Immunol. 126(4):871-873(2010)
Background Reference 2:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 3:
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 4:
Perlis, R.H., et al. Biol. Psychiatry 67(11):1110-1113(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-410

List Size:
400 ul

List Price:

$469.00

Out of stock

Datasheet
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