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Western blot analysis in Ramos cell line lysates (35ug/lane).
Flow cytometric analysis of Ramos cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Western blot analysis in Ramos cell line lysates (35ug/lane).

PDE4B Antibody

CATALOG NUMBER: 55-986

Clonality:
Polyclonal
Tested Applications:
Flow, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This PDE4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-217 amino acids from the Central region of human PDE4B.
Conjugate:
Unconjugated
Tested Applications:
Flow, WB
Application Note:
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
Predicted Molecular Weight:
83 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PDE4B
Additional Names:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B, DPDE4, PDE32, PDE4B, DPDE4
Protein Accession Number:
Q07343
Protein Gi Number:
729163
Ncbi Gene Id Number:
5142
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene is a member of the type IV, cyclic AMP(cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family.Cyclic nucleotides are important second messengers that regulateand mediate a number of cellular responses to extracellularsignals, such as hormones, light, and neurotransmitters. The cyclicnucleotide phosphodiesterases (PDEs) regulate the cellularconcentrations of cyclic nucleotides and thereby play a role insignal transduction. This gene encodes a protein that specificallyhydrolyzes cAMP. Altered activity of this protein has beenassociated with schizophrenia and bipolar affective disorder.Alternate transcriptional splice variants, encoding differentisoforms, have been characterized.
Background Reference 1:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 2:
Souza, R.P., et al. Int Clin Psychopharmacol 25(5):264-269(2010)
Background Reference 3:
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 4:
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

55-986

List Size:
400 ul

List Price:

$495.00

Datasheet
Shipping Info

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