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Western blot analysis in K562 cell line lysates (35ug/lane).
Western blot analysis in K562 cell line lysates (35ug/lane).

PDE6A Antibody

CATALOG NUMBER: 56-928

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This PDE6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDE6A.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
100 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PDE6A
Additional Names:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha, GMP-PDE alpha, PDE V-B1, PDE6A, PDEA
Protein Accession Number:
P16499
Protein Gi Number:
215274230
Ncbi Gene Id Number:
5145
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes the cyclic-GMP (cGMP)-specificphosphodiesterase 6A alpha subunit, expressed in cells of theretinal rod outer segment. The phosphodiesterase 6 holoenzyme is aheterotrimer composed of an alpha, beta, and two gamma subunits.cGMP is an important regulator of rod cell membrane current, andits dynamic concentration is established by phosphodiesterase 6AcGMP hydrolysis and guanylate cyclase cGMP synthesis. The proteinis a subunit of a key phototransduction enzyme and participates inprocesses of transmission and amplification of the visual signal.Mutations in this gene have been identified as one cause ofautosomal recessive retinitis pigmentosa.
Background Reference 1:
Clark, G.R., et al. Ophthalmology 117(11):2169-2177(2010)
Background Reference 2:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 3:
Perlis, R.H., et al. Biol. Psychiatry 67(11):1110-1113(2010)
Background Reference 4:
Bazhin, A.V., et al. Cell. Mol. Life Sci. 67(5):817-828(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

56-928

List Size:
400 ul

List Price:

$495.00

Datasheet
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