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PDGF-AB Recombinant Protein

CATALOG NUMBER: 40-512

Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
Alpha Chain: SIEEAVPAV CKTRTVIYEI PRSQVDPTSA NFLIWPPCVE VKRCTGCCNT SSVKCQPSRV HHRSVKVAKV EYVRKKPKLK EVQVRLEEHL ECACATTSLN PDYREEDTGR PRESGKKRKR KRLKPT

Beta Chain: SLGSLTIAE PAMIAECKTR TEVFEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRPTQVQLRP VQVRKIGIVR KKPIFKKATV TLGDHLACKC ETVAAARPVT
Biological Activity:
The ED50 was determined by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells is ≤ 1 ng/mL, corresponding to a specific activity of ≥ 1 x 106 units/mg.
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
physical-state:
Lyophilized
Storage Conditions:
The lyophilized PDGF-AB recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted PDGF-AB is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing PDGF-AB recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Ncbi Official Symbol:
PDGFA
Additional Names:
PDGF1, PDGF-A, PDGF1, Platelet-derived growth factor subunit A, PDGF-1, PDGF subunit A
Protein Accession Number:
NP_002598.4
Protein Gi Number:
77695917
Ncbi Gene Id Number:
5154;5155
Background:
PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-B. PDGFR-a is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-B interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AB is a 26.4 kDa disulfide-linked dimer, consisting of one A chain and one B chains (234 total amino acids).

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

40-512

List Size:
0.002 mg, 0.01 mg

List Price:

Price range: $215.00 through $323.00

Datasheet
Shipping Info

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