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Western blot analysis of extracts from HepG2 cells treated with EGF using Phospho-PDGFR beta (Tyr740) Antibody. The lane on the right is treated with the antigen-specific peptide.
Western blot analysis of extracts from HepG2 cells treated with EGF using Phospho-PDGFR beta (Tyr740) Antibody. The lane on the right is treated with the antigen-specific peptide.

PDGFR beta (phospho Tyr740) Antibody

CATALOG NUMBER: 79-991

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
PDGFR beta (phospho Tyr740) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 740 (G-G-Y (p)-M-D) derived from Human PDGFR beta.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:500~1:1000
Specificity:
The antibody detects endogenous level of PDGFR beta only when phosphorylated at tyrosine 740.
Predicted Molecular Weight:
170 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
PDGFRB
Additional Names:
CD140b, PDGF-R-beta, PDGFR, PGFRB, kinase PDGFR-beta
Protein Accession Number:
NP_002600.1
Protein Gi Number:
129890
Ncbi Gene Id Number:
5159
Background:
PDGF Receptor β encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
Background Reference 1:
Mitchell D, et al. (2007) J Biol Chem 282, 15606-18Wu JH, et al. (2006) J Biol Chem 281, 37758-72 . Bae YS, et al. (2000)J Biol Chem 275, 10527-31.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-991

List Size:
0.1 mg

List Price:

$355.00

Out of stock

Datasheet
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