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Cynomolgus / Rhesus macaque PD-L1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Cynomolgus / Rhesus macaque PD-L1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

PDL1 Recombinant Protein

CATALOG NUMBER: 96-594

Tested Applications:
WB
Specifications
source-species:
HEK293 cells
Species:
Cynomolgus monkey
source-species:
HEK293 cells
Recombinant Protein Sequence:
Glu 25 - Pro 297
Fusion Tag:
His Tag
Tested Applications:
WB
Application Note:
This recombinant protein can be used for WB. For research use only.
Predicted Molecular Weight:
27.1 kDa
Biological Activity:
Immobilized Cynomolgus PD-L1, His Tag at 10 ug/mL (100 ul/well) can bind Cynomolgus PD-1, Fc Tag with a linear range of 0.6-10 ug/mL.
Purity:
>95% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Additional Names:
PD-L1, CD274, B7-H1, PDCD1L1, PDCD1LG1
Protein Accession Number:
F6VEW6
Background:
Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.
Background Reference 1:
Dong H., et al., 1999, Nat. Med. 5:1365-1369. (2) Freeman G.J., et al., 2000, J. Exp. Med. 192:1027-1034. (3) Nishimura H., et al., 2001, Trends in Immunology 22:265. 
Background Reference 2:
Freeman G.J., et al., 2000, J. Exp. Med. 192:1027-1034.
Background Reference 3:
Nishimura H., et al., 2001, Trends in Immunology 22:265. 

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-594

List Size:
0.1 mg

List Price:

$577.00

Datasheet
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