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Western blot analysis of PEAR1 in rat kidney tissue lysate with PEAR1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of PEAR1 in human kidney tissue with PEAR1 antibody at 2.5 μg/mL.
Immunofluorescence of PEAR1 in human kidney tissue with PEAR1 antibody at 20 μg/mL.
Western blot analysis of PEAR1 in rat kidney tissue lysate with PEAR1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Trial Size

PEAR1 Antibody

CATALOG NUMBER: 6055

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
PEAR1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human PEAR1.
The immunogen is located within the last 50 amino acids of PEAR1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
PEAR1 antibody can be used for detection of PEAR1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1465 - Rat Kidney Tissue Lysate
Positive Control 2:
Cat. No. 10-401 - Human Kidney Tissue Slide
Purification:
PEAR1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
PEAR1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
PEAR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PEAR1
Additional Names:
PEAR1 Antibody: JEDI, MEGF12, Platelet endothelial aggregation receptor 1, Multiple epidermal growth factor-like domains protein 12, hPEAR1
Protein Accession Number:
NP_001073940
Protein Gi Number:
122937343
Ncbi Gene Id Number:
375033
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
PEAR1 Antibody: Platelet endothelial aggregation receptor 1 (PEAR1) is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation. Upon platelet aggregation stimulated by physiological agonists, PEAR1 becomes tyrosine- and serine-phosphorylated; the tyrosine phosphorylation can be inhibited by eptifibatide, an aIIbbeta3 antagonist that also inhibits platelet aggregation. Recent studies have indicated that genetic variations in PEAR1, may be associated with enhanced agonist-induced platelet aggregation.
Background Reference 1:
Nanda N, Bao M, Lin H, et al. Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in the platelet contact-induced activation. J. Biol. Chem.2005; 280:24680-9.
Background Reference 2:
Herrera-Galeano JE, Becker DM, Wilson AF, et al. A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregabili. Arterioscler. Thromb. Vasc. Biol.2008; 28:1484-90.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6055

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.

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