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Western blot analysis of extracts from Jurkat tissue using PECAM-1 (Phospho-Tyr713) Antibody. The lane on the right is treated with the antigen-specific peptide.
Western blot analysis of extracts from Jurkat tissue using PECAM-1 (Phospho-Tyr713) Antibody. The lane on the right is treated with the antigen-specific peptide.

PECAM-1 (phospho Tyr713) Antibody

CATALOG NUMBER: 80-043

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
PECAM-1 (phospho Tyr713) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine 713 (T-V-Y (p)-S-E) derived from Human PECAM-1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:500~1:1000
Specificity:
The antibody detects endogenous level of PECAM-1 only when phosphorylated at tyrosine 713.
Predicted Molecular Weight:
82, 150 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
PECAM1
Additional Names:
CD31, CD31 antigen, EndoCAM, PEC1, PECAM
Protein Accession Number:
NP_000433.4
Protein Gi Number:
313760624
Ncbi Gene Id Number:
5175
Background:
Induces susceptibility to atherosclerosis By similarity. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte.
Background Reference 1:
Garnacho C, et al. (2008) Blood 111, 3024-33. Udell CM, et al. (2006) J Biol Chem 281, 20949-57 . O'Brien CD, Cao G, Makrigiannakis A, DeLisser HM (2004)Am J Physiol Cell Physiol 287, C1103-13.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

80-043

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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