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PEK/PERK (phospho Thr982) Antibody

CATALOG NUMBER: 79-862

Clonality:
Polyclonal
Tested Applications:
IHC
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
PEK/PERK (phospho Thr982) antibody was raised against a peptide sequence around phosphorylation site of threonine 981 (A-R-H (p)-T-G) derived from Human PEK/PERK.
Conjugate:
Unconjugated
Tested Applications:
IHC
Specificity:
The antibody detects endogenous levels of PEK/PERK only when phosphorylated at threonine 981.
Predicted Molecular Weight:
125 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
EIF2AK3
Additional Names:
E2AK3, PERK, PEK, EIF2AK3
Protein Accession Number:
NP_004827.4
Protein Gi Number:
296439367
Ncbi Gene Id Number:
9451
Background:
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1)
Background Reference 1:
Shi Y., An J., J. Biol. Chem. 274:5723-5730(1999).
Background Reference 2:
Sood R., Biochem. J. 346:281-293(2000).
Background Reference 3:
The MGC Project Team; Genome Res. 14:2121-2127(2004).

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-862

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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