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Western blot analysis in mouse liver tissue lysates (35ug/lane).
PIK3C2A Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in mouse liver tissue lysates (35ug/lane).

PIK3C2A Antibody

CATALOG NUMBER: 56-082

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Mouse
Immunogen:
This PIK3C2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1431-1458 amino acids from the C-terminal region of human PIK3C2A.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
191 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PIK3C2A
Additional Names:
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PI3K-C2-alpha, PtdIns-3-kinase C2 subunit alpha, Phosphoinositide 3-kinase-C2-alpha, PIK3C2A
Protein Accession Number:
O00443
Ncbi Gene Id Number:
5286
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene belongs to thephosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles insignaling pathways involved in cell proliferation, oncogenictransformation, cell survival, cell migration, and intracellularprotein trafficking. This protein contains a lipid kinase catalyticdomain as well as a C-terminal C2 domain, a characteristic of classII PI3-kinases. C2 domains act as calcium-dependent phospholipidbinding motifs that mediate translocation of proteins to membranes,and may also mediate protein-protein interactions. The PI3-kinaseactivity of this protein is not sensitive to nanomolar levels ofthe inhibitor wortmanin. This protein was shown to be able to beactivated by insulin and may be involved in integrin-dependentsignaling.
Background Reference 1:
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Background Reference 2:
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 3:
Kostakis, G.C., et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109 (5), E53-E58 (2010) :
Background Reference 4:
Koutros, S., et al. Cancer Res. 70(6):2389-2396(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

56-082

List Size:
400 ul

List Price:

$469.00

Out of stock

Datasheet
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