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Western blot analysis of PIK3C3 in mouse small intestine tissue lysate with PIK3C3 antibody at 1 μg/ml.
Western blot analysis of PIK3C3 in mouse small intestine tissue lysate with PIK3C3 antibody at 1 μg/ml.
Trial Size

PIK3C3 Antibody

CATALOG NUMBER: 7891

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Pig: (100%)
Immunogen:
PIK3C3 antibody was raised against an 18 amino acid peptide near the amino terminus of human PIK3C3.
The immunogen is located within amino acids 130 - 180 of PIK3C3.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
PIK3C3 antibody can be used for detection of PIK3C3 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Specificity:
PIK3C3 antibody is human, mouse and rat reactive.
Positive Control 1:
Cat. No. 1408 - Mouse Small Intestine Tissue Lysate
Predicted Molecular Weight:
Predicted: 91, 98 kDa
Observed: 98 kDa
Purification:
PIK3C3 antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
PIK3C3 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
PIK3C3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
PIK3C3
Additional Names:
PIK3C3 Antibody: VPS34, hVps34, VPS34, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphatidylinositol 3-kinase p100 subunit, PI3-kinase type 3
Protein Accession Number:
NP_002638
Protein Gi Number:
34761064
Ncbi Gene Id Number:
5289
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
PI 3-kinase p100 (phosphoinositide-3-kinase p100 subunit), also known as hVps34 or PIK3C3 (phosphoinositide-3-kinase class III), is a member of the PI3/PI4-kinase family (1). It is a catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate and ubiquitously expressed with a highest expression in skeletal muscle (1,2). PIK3C3 is involved in the endosome to lysosome transport and plays important roles in intracellular membrane trafficking and autophagy (3-5).
Background Reference 1:
Stopkova P, Saito T, Papolos DF, et al. Identification of PIK3C3 promoter variant associated with bipolar disorder and schizophrenia. Biol. Psychiatry 2004; 55:981-8.
Background Reference 2:
Hal BS, Gabernet-Castello C, Voak A, et al. TbVps34, the trypanosome orthologue of Vps34, is required for Golgi complex segregation. J. Biol. Chem. 2006; 281:27600-12.
Background Reference 3:
Backer JM. The regulation and function of class III PI3Ks: novel roles for Vps34. Biochem. J. 2008; 410:1-17.
Background Reference 4:
Jaber N, Dou Z, Lin RZ, et al. Mammalian PIK3C3/VPS34: the key to autophagic processing in liver and heart. Autophagy 2012; 8:707-8.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7891

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

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