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Western blot analysis of extracts from COS7 cells treated with Insulin using Phospho-Pin1 (Ser16) Antibody. The lane on the right is treated with the antigen-specific peptide.
Western blot analysis of extracts from COS7 cells treated with Insulin using Phospho-Pin1 (Ser16) Antibody. The lane on the right is treated with the antigen-specific peptide.

Pin1 (phospho Ser16) Antibody

CATALOG NUMBER: 80-010

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Pin1 (phospho Ser16) antibody was raised against a peptide sequence around phosphorylation site of serine16 (R-M-S (p)-R-S) derived from Human Pin1 .
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:500~1:1000
Specificity:
The antibody detects endogenous level of Pin1 only when phosphorylated at serine 16.
Predicted Molecular Weight:
18 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
PIN1
Additional Names:
PPIase Pin1, Rotamase Pin1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, EC 5.2.1.8,
Protein Accession Number:
NP_006212.1
Protein Gi Number:
5453898
Ncbi Gene Id Number:
5300
Background:
Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner.
Background Reference 1:
Lee YC, et al. (2013)J Cell Sci 126, 4862-72. Ando K, et al. (2013)Neurobiol Aging 34, 757-69. Nechama M, Lin CL, Richter JD (2013)Mol Cell Biol 33, 48-58.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

80-010

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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