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Western blot analysis in CEM cell line lysates (35ug/lane).
Western blot analysis in CEM cell line lysates (35ug/lane).

PITX2 Antibody

CATALOG NUMBER: 57-422

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This PITX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-71 amino acids from the N-terminal region of human PITX2.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
35 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PITX2
Additional Names:
Pituitary homeobox 2, ALL1-responsive protein ARP1, Homeobox protein PITX2, Paired-like homeodomain transcription factor 2, RIEG bicoid-related homeobox transcription factor, Solurshin, PITX2, ARP1, RGS, RIEG, RIEG1
Protein Accession Number:
Q99697
Protein Gi Number:
6174907
Ncbi Gene Id Number:
5308
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a member of the RIEG/PITX homeoboxfamily, which is in the bicoid class of homeodomain proteins. Theencoded protein acts as a transcription factor and regulatesprocollagen lysyl hydroxylase gene expression. This protein plays arole in the terminal differentiation of somatotroph and lactotrophcell phenotypes, is involved in the development of the eye, toothand abdominal organs, and acts as a transcriptional regulatorinvolved in basal and hormone-regulated activity of prolactin.Mutations in this gene are associated with Axenfeld-Riegersyndrome, iridogoniodysgenesis syndrome, and sporadic cases ofPeters anomaly. A similar protein in other vertebrates is involvedin the determination of left-right asymmetry during development.Alternatively spliced transcript variants encoding distinctisoforms have been described.
Background Reference 1:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 2:
Banez, L.L., et al. J. Urol. 184(1):149-156(2010)
Background Reference 3:
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)
Background Reference 4:
Ellinor, P.T., et al. Nat. Genet. 42(3):240-244(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-422

List Size:
400 ul

List Price:

$495.00

Datasheet
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