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Western blot analysis of lysed extracts from HT29 cells using PKCΘ (Ab-695).
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using PKCΘ (Ab-695).
Western blot analysis of lysed extracts from HT29 cells using PKCΘ (Ab-695).

PKCtheta (Ab 695) Antibody

CATALOG NUMBER: 79-353

Clonality:
Polyclonal
Tested Applications:
IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
PKCtheta (Ab-695) antibody was raised against a peptide sequence around aa.693~697 (N-F-S-F-M) derived from Human PKCΘ.
Conjugate:
Unconjugated
Tested Applications:
IHC, WB
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Specificity:
This antibody detects endogenous level of total PKCΘ protein.
Predicted Molecular Weight:
80 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
PRKCQ
Additional Names:
PRKCT, nPKC-theta, MAPTL, MTBT1, TAU, KPCT, PKC-theta, PKCQ, PRKCQ, PRKCT
Protein Accession Number:
NP_006248.1
Protein Gi Number:
5453976
Ncbi Gene Id Number:
5588
Background:
This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-κ-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
Background Reference 1:
Xu ZB, et al. (2004) J Biol Chem 279:50401-50409Thebault S, et al. (2004) Mol Immunol 40: 931-942

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-353

List Size:
0.1 mg

List Price:

$370.00

Datasheet
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