PKP2 Antibody

CATALOG NUMBER: 56-747

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This PKP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 838-866 amino acids from the C-terminal region of human PKP2.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
97 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PKP2
Additional Names:
Plakophilin-2, PKP2
Protein Accession Number:
Q99959
Protein Gi Number:
296452867
Ncbi Gene Id Number:
5318
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a member of the arm-repeat (armadillo)and plakophilin gene families. Plakophilin proteins containnumerous armadillo repeats, localize to cell desmosomes and nuclei,and participate in linking cadherins to intermediate filaments inthe cytoskeleton. This gene product may regulate the signalingactivity of beta-catenin. Two alternately spliced transcriptsencoding two protein isoforms have been identified. A processedpseudogene with high similarity to this locus has been mapped tochromosome 12p13.
Background Reference 1:
Fressart, V., et al. Europace 12(6):861-868(2010)
Background Reference 2:
Cox, M.G., et al. Circ Arrhythm Electrophysiol 3(2):126-133(2010)
Background Reference 3:
Christensen, A.H., et al. Cardiology 115(2):148-154(2010)
Background Reference 4:
den Haan, A.D., et al. Circ Cardiovasc Genet 2(5):428-435(2009)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

56-747

List Size:
400 ul

List Price:

$495.00

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