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Western blot analysis of PLAC4 in human placenta tissue lysate with PLAC4 antibody at (A) 1 and (B) 2 μg/mL.
Immunocytochemistry of PLAC4 in HeLa cells with PLAC4 antibody at 10 μg/mL.
Immunofluorescence of PLAC4 in HeLa cells with PLAC4 antibody at 20 μg/mL.
Western blot analysis of PLAC4 in human placenta tissue lysate with PLAC4 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

PLAC4 Antibody

CATALOG NUMBER: 6021

Clonality:
Polyclonal
Tested Applications:
ELISA, ICC, IF, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
PLAC4 antibody was raised against a 17 amino acid synthetic peptide near the center of human PLAC4.
The immunogen is located within amino acids 20 - 70 of PLAC4.
Conjugate:
Unconjugated
Tested Applications:
ELISA, ICC, IF, WB
Application Note:
PLAC4 antibody can be used for detection of PLAC4 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1309 - Human Placenta Tissue Lysate
Positive Control 2:
Cat. No. 17-001 - HeLa Cell Slide
Purification:
PLAC4 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
PLAC4 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
PLAC4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PLAC4
Additional Names:
PLAC4 Antibody: PRED78, C21orf115, D21S418E, PP1416, Placenta-specific protein 4
Protein Accession Number:
NP_878252
Protein Gi Number:
121949815
Ncbi Gene Id Number:
191585
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
PLAC4 Antibody: PLAC4 (placenta-specific protein 4), was initially discovered as a gene whose mRNA was expressed in placental syncytiotrophoblast and choriocarcinoma cells. While the function of PLAC4 is currently unclear, its gene is known to be located on chromosome 21q22.3. Due to the PLAC4 gene location on chromosome 21 and the release of its mRNA transcripts into maternal bloodstream from the placenta, it has been proposed to be a useful marker noninvasive prenatal chromosome 21 aneuploidy detection, although other reports suggests that PLAC4 mRNA levels are not altered in the maternal circulation of pregnancies with trisomy 21.
Background Reference 1:
Kido S, Sakuragi N, Bronner MP, et al. D21S418E identifies a cAMP-regulated gene located on chromosome 21q22.3 that is expressed in placental syncytiotrophoblast and choriocarcinoma. Genomics1993; 17:256-9.
Background Reference 2:
Lo YMD, Tsui NBY, Chiu RWK, et al. Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection. Nat. Med.2007; 13:218-223.
Background Reference 3:
Tsui NB, Akolekar R, Chiu RW, et al. Synergy of total PLAC4 RNA concentration and measurement of the RNA single-nucleotide polymorphism allelic ratio for the noninvasive prenatal detection of trisomy 21. Clin. Chem.2010; 56:73-81.
Background Reference 4:
Banzola I, Rusterholz C, Zannoni L, et al. PLAC4 and beta-HCG mRNA levels are not altered in the maternal circulation of pregnancies with trisomy 21. Prenat. Diagn.2008; 28:1262-7.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6021

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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