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Western blot analysis of lysate from U266 cell line,using PLN Antibody at 1:1000 at each lane
Western blot analysis of lysate from U266 cell line,using PLN Antibody at 1:1000 at each lane

PLN Antibody

CATALOG NUMBER: 61-011

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig, Rabbit, Rat
Immunogen:
This PLN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1-22 amino acids from the N-terminal region of human PLN.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
6 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PLN
Additional Names:
Cardiac phospholamban, PLB, PLN, PLB
Protein Accession Number:
P26678
Protein Gi Number:
130774
Ncbi Gene Id Number:
5350
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2 Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
Background Reference 1:
Fujii J.,et al.J. Biol. Chem. 266:11669-11675(1991).
Background Reference 2:
Salvatore C.A.,et al.Submitted (MAR-1991) to the EMBL/GenBank/DDBJ databases.
Background Reference 3:
McTiernan C.F.,et al.J. Mol. Cell. Cardiol. 31:679-692(1999).
Background Reference 4:
Minamisawa S.,et al.Biochem. Biophys. Res. Commun. 304:1-4(2003).

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

61-011

List Size:
400 ul

List Price:

$495.00

Datasheet
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