POF1B Antibody

CATALOG NUMBER: 57-299

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Mouse
Immunogen:
This POF1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 337-366 amino acids from the Central region of human POF1B.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
68 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
POF1B
Additional Names:
Protein POF1B, Premature ovarian failure protein 1B, POF1B
Protein Accession Number:
Q8WVV4
Protein Gi Number:
332278224
Ncbi Gene Id Number:
79983
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Premature ovarian failure (POF) is characterized byprimary or secondary amenorrhea in women less than 40 years old.Two POF susceptibility regions called 'POF1' and 'POF2' have beenidentified by breakpoint mapping of X-autosome translocations. POF1extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1.This gene, POF1B, resides in the POF2 region. This gene isexpressed at trace levels in mouse prenatal ovary and is barelydetectable or absent from adult ovary, in human and in the mouserespectively. This gene's expression is restricted to epitheliawith its highest expression in the epidermis, and oro-pharyngealand gastro-intestinal tracts. The protein encoded by this genebinds non-muscle actin filaments. The role this gene may play inthe etiology of premature ovarian failure remains to be determined.
Background Reference 1:
Rizzolio, F., et al. Gene Expr. Patterns 7(4):529-534(2007)
Background Reference 2:
Lacombe, A., et al. Am. J. Hum. Genet. 79(1):113-119(2006)
Background Reference 3:
Bione, S., et al. Hum. Reprod. 19(12):2759-2766(2004)
Background Reference 4:
Bione, S., et al. Semin. Reprod. Med. 18(1):51-57(2000)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-299

List Size:
400 ul

List Price:

$495.00

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