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Potassium Channel, Kv2.2 Subunit Antibody
Potassium Channel, Kv2.2 Subunit Antibody

Potassium Channel Antibody

CATALOG NUMBER: XPS-2027

Clonality:
Polyclonal
Tested Applications:
IHC, WB
Host Species:
Rabbit
Species Reactivity:
Frog, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Frog, Rat
Immunogen:
Potassium Channel, Kv2.
Conjugate:
Unconjugated
Tested Applications:
IHC, WB
Application Note:
Potassium Channel antibody can be used for specific immunolabeling of the ~125k Kv 2.2 protein in Western blots. Applications include Dot Blots (DB), Immunohistochemistry (IHC) and Western Blots (WB). Rabbit anti-Potassium Channel, Kv2.2 recognizes Kv2.2 in rat and Xenopus. When internally tested under ideal conditions the working dilutions were 1:1000 for IHC, DB and WB.
Predicted Molecular Weight:
100
Purification:
Affinity Purified
Clonality:
Polyclonal
Physical State:
Liquid
Concentration:
batch dependent
Storage Conditions:
Potassium Channel, Kv2.2 Subunit antibody can be stored at -20°C. After reconstitution in 50 μl PBS, the antibody should be aliquot and stored at -20°C and is stable at -20°C for at least 1 year. Ambient shipment is suitable for both international and domestic.
Ncbi Official Symbol:
Kcnb2
Protein Accession Number:
Q63099
Protein Gi Number:
24418850
Ncbi Gene Id Number:
117105
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Voltage-gated K+ channels are important determinants of neuronal membrane excitability, and differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety on non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes. Kv2.1 and Kv2.2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells.
Background Reference 1:
Burger, C. and Ribera, A.B. "Xenopus spinal neurons express Kv2 potassium channel transcripts during embryonic development," J Neurosci. 16 (1996) 1412 - 1421.
Background Reference 2:
Pongs, O. "Voltage-gated potassium channels: from hyperexcitability to excitement," FEBS Lett. 452 (1999) 31-35.
Background Reference 3:
Maletic-Savatic, M., Lenn, N.J., and Trimmer, J.S. "Differential spatiotemporal expression of K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro," J Neurosci. 15 (1995) 3840-3851.
Background Reference 4:
Hwang, P.M., Fotuhi, M., Bredt, D.S., Cunningham, A.M., and Snyder, S.H. "Contrasting immunohistochemical localizations in rat brain of two novel K+ channels of the Shab subfamily," J. Neurosci., 13 (1993) 1569 - 1576.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

XPS-2027

List Size:
0.1 mL

List Price:

$540.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.

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