PPAN Antibody

CATALOG NUMBER: 57-374

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This PPAN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 422-450 amino acids from the C-terminal region of human PPAN.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
53 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PPAN
Additional Names:
Suppressor of SWI4 1 homolog, Ssf-1, Brix domain-containing protein 3, Peter Pan homolog, PPAN, BXDC3, SSF1
Protein Accession Number:
Q9NQ55
Protein Gi Number:
21264056
Ncbi Gene Id Number:
56342692312
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene is an evolutionarilyconserved protein similar to yeast SSF1 as well as to the geneproduct of the Drosophila gene peter pan (ppan). SSF1 is known tobe involved in the second step of mRNA splicing. Both SSF1 and ppanare essential for cell growth and proliferation. Exogenousexpression of this gene was reported to reduce theanchorage-independent growth of some tumor cells. Read-throughtranscription of this gene with P2RY11/P2Y(11), an adjacentdownstream gene that encodes an ATP receptor, has been found. Theseread-through transcripts are ubiquitously present and up-regulatedduring granulocyte differentiation.
Background Reference 1:
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Background Reference 2:
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Background Reference 3:
Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)
Background Reference 4:
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-374

List Size:
400 ul

List Price:

$495.00

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