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Western blot analysis in human placenta tissue lysates (35ug/lane).
Western blot analysis in human placenta tissue lysates (35ug/lane).

PPARD Antibody

CATALOG NUMBER: 57-265

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This PPARD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-393 amino acids from the C-terminal region of human PPARD.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
50 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PPARD
Additional Names:
Peroxisome proliferator-activated receptor delta, PPAR-delta, NUCI, Nuclear hormone receptor 1, NUC1, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated receptor beta, PPAR-beta, PPARD, NR1C2, PPARB
Protein Accession Number:
Q03181
Protein Gi Number:
417522
Ncbi Gene Id Number:
5467
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a member of the peroxisomeproliferator-activated receptor (PPAR) family. PPARs are nuclearhormone receptors that bind peroxisome proliferators and controlthe size and number of peroxisomes produced by cells. PPARs mediatea variety of biological processes, and may be involved in thedevelopment of several chronic diseases, including diabetes,obesity, atherosclerosis, and cancer. This protein is a potentinhibitor of ligand-induced transcription activity of PPAR alphaand PPAR gamma. It may function as an integrator of transcriptionrepression and nuclear receptor signaling. The expression of thisgene is found to be elevated in colorectal cancer cells. Theelevated expression can be repressed by adenomatosis polyposis coli(APC), a tumor suppressor protein related to APC/beta-cateninsignaling pathway. Knockout studies in mice suggested the role ofthis protein in myelination of the corpus callosum, lipidmetabolism, and epidermal cell proliferation. Alternate splicingresults in multiple transcript variants.
Background Reference 1:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 2:
Christopoulos, P., et al. Ann. N. Y. Acad. Sci. 1205, 185-191 (2010) :
Background Reference 3:
Dunn, S.E., et al. J. Exp. Med. 207(8):1599-1608(2010)
Background Reference 4:
Eynon, N., et al. Mitochondrion (2010) In press :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-265

List Size:
400 ul

List Price:

$495.00

Datasheet
Shipping Info

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