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Western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstratesdetected the PPM1A protein (arrow).
Western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstratesdetected the PPM1A protein (arrow).

PPM1A Antibody

CATALOG NUMBER: 57-641

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Rabbit
Immunogen:
This PPM1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-382 amino acids from human PPM1A.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
42 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PPM1A
Additional Names:
Protein phosphatase 1A, Protein phosphatase 2C isoform alpha, PP2C-alpha, Protein phosphatase IA, PPM1A, PPPM1A
Protein Accession Number:
P35813
Protein Gi Number:
548442
Ncbi Gene Id Number:
5494
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene is a member of the PP2Cfamily of Ser/Thr protein phosphatases. PP2C family members areknown to be negative regulators of cell stress response pathways.This phosphatase dephosphorylates, and negatively regulates theactivities of, MAP kinases and MAP kinase kinases. It has beenshown to inhibit the activation of p38 and JNK kinase cascadesinduced by environmental stresses. This phosphatase can alsodephosphorylate cyclin-dependent kinases, and thus may be involvedin cell cycle control. Overexpression of this phosphatase isreported to activate the expression of the tumor suppressor geneTP53/p53, which leads to G2/M cell cycle arrest and apoptosis.Three alternatively spliced transcript variants encoding distinctisoforms have been described.
Background Reference 1:
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 2:
Zhang, B., et al. Histochem. Cell Biol. 132(2):169-179(2009)
Background Reference 3:
Sun, W., et al. Cell. Signal. 21(1):95-102(2009)
Background Reference 4:
Wang, Y., et al. J. Biol. Chem. 283(48):33578-33584(2008)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-641

List Size:
400 ul

List Price:

$495.00

Datasheet
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