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Western blot analysis in mouse heart tissue lysates (15ug/lane).This demonstrates the detected PRELP protein (arrow).
PRELP Antibody IHC analysis in formalin fixed and paraffin embedded breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in mouse heart tissue lysates (15ug/lane).This demonstrates the detected PRELP protein (arrow).

PRELP Antibody

CATALOG NUMBER: 62-389

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This PRELP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-148 amino acids from the Central region of human PRELP.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
Predicted Molecular Weight:
44 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PRELP
Additional Names:
Prolargin, Proline-arginine-rich end leucine-rich repeat protein, PRELP, SLRR2A
Protein Accession Number:
P51888
Protein Gi Number:
1709586
Ncbi Gene Id Number:
5549
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
PRELP is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage.
Background Reference 1:
Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)
Background Reference 2:
Grover, J., et al. Matrix Biol. 26(2):140-143(2007)
Background Reference 3:
Johnson, J.M., et al. Mol. Vis. 12, 1057-1066 (2006)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

62-389

List Size:
400 ul

List Price:

$495.00

Datasheet
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