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Human Prolactin R, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Human Prolactin, Mouse IgG2a Fc Tag, low endotoxin at 1 ug/mL (100 uL/well) can bind Human Prolactin R, Fc Tag with a linear range of 2-39 ng/mL (QC tested).
Immobilized Human GH, Tag Free at 2 ug/mL (100 uL/well) can bind Human Prolactin R, Fc Tag with a linear range of 0.4-6 ng/mL (Routinely tested).
Human Prolactin R, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Prolactin R / PRLR Recombinant Protein

CATALOG NUMBER: 11-529

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Gln 25 - Asp 234
Fusion Tag:
Fc Tag
Tested Applications:
ELISA, WB
Application Note:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.0 kDa. The protein migrates as 64 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight:
51.0 kDa
Purity:
>95% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
Tris with Glycine, Arginine and NaCl, pH7.5
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
PRLR
Additional Names:
Prolactin R,PRLR,PRL-R
Protein Accession Number:
NP_000940.1
Ncbi Gene Id Number:
5618
Background:
As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. In addition, the PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Preclinical investigations, epidemiological studies and analyses of tissue specimens from patients strongly support the contribution of prolactin receptor (PRLR) signaling to breast and prostate tumorigenesis and cancer progression. Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.
Background Reference 1:
Pujianto DA., et al., 2010, Endocrinology. 151(3):1269-79. (2) Trott JF., et al.,2003, J Mol Endocrinol, 30:31-47. (3) Goffin V., et al., 2017, Pharmacol Ther. 179:111-126.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-529

List Size:
0.1 mg

List Price:

$577.00

Datasheet
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