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Western blot analysis in MCF-7 cell line lysates (35ug/lane).
Western blot analysis in MCF-7 cell line lysates (35ug/lane).

PTBP1 Antibody

CATALOG NUMBER: 60-675

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This PTBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human PTBP1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
57 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PTBP1
Additional Names:
Polypyrimidine tract-binding protein 1, PTB, 57 kDa RNA-binding protein PPTB-1, Heterogeneous nuclear ribonucleoprotein I, hnRNP I, PTBP1, PTB
Protein Accession Number:
P26599
Protein Gi Number:
131528
Ncbi Gene Id Number:
5725
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene belongs to the subfamily of ubiquitouslyexpressed heterogeneous nuclear ribonucleoproteins (hnRNPs). ThehnRNPs are RNA-binding proteins and they complex with heterogeneousnuclear RNA (hnRNA). These proteins are associated with pre-mRNAsin the nucleus and appear to influence pre-mRNA processing andother aspects of mRNA metabolism and transport. While all of thehnRNPs are present in the nucleus, some seem to shuttle between thenucleus and the cytoplasm. The hnRNP proteins have distinct nucleicacid binding properties. The protein encoded by this gene has fourrepeats of quasi-RNA recognition motif (RRM) domains that bindRNAs. This protein binds to the intronic polypyrimidine tracts thatrequires pre-mRNA splicing and acts via the protein degradationubiquitin-proteasome pathway. It may also promote the binding of U2snRNP to pre-mRNAs. This protein is localized in the nucleoplasmand it is also detected in the perinucleolar structure.Alternatively spliced transcript variants encoding differentisoforms have been described.
Background Reference 1:
Kanda, T., et al. J. Viral Hepat. 17(9):618-623(2010)
Background Reference 2:
Cobbold, L.C., et al. Oncogene 29(19):2884-2891(2010)
Background Reference 3:
Verma, B., et al. J. Gen. Virol. 91 (PT 5), 1245-1255 (2010) :
Background Reference 4:
Maynard, C.M., et al. J. Mol. Biol. 397(1):260-277(2010)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-675

List Size:
400 ul

List Price:

$495.00

Datasheet
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