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Western blot analysis in mouse testis tissue lysates (35ug/lane).
Western blot analysis in mouse testis tissue lysates (35ug/lane).

PTPN1 Antibody

CATALOG NUMBER: 60-913

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Mouse
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This PTPN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-249 amino acids from the Central region of human PTPN1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
50 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PTPN1
Additional Names:
Tyrosine-protein phosphatase non-receptor type 1, Protein-tyrosine phosphatase 1B, PTP-1B, PTPN1, PTP1B
Protein Accession Number:
P18031
Protein Gi Number:
131467
Ncbi Gene Id Number:
5770
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene is the founding member ofthe protein tyrosine phosphatase (PTP) family, which was isolatedand identified based on its enzymatic activity and amino acidsequence. PTPs catalyze the hydrolysis of the phosphate monoestersspecifically on tyrosine residues. Members of the PTP family sharea highly conserved catalytic motif, which is essential for thecatalytic activity. PTPs are known to be signaling molecules thatregulate a variety of cellular processes including cell growth,differentiation, mitotic cycle, and oncogenic transformation. ThisPTP has been shown to act as a negative regulator of insulinsignaling by dephosphorylating the phosphotryosine residues ofinsulin receptor kinase. This PTP was also reported todephosphorylate epidermal growth factor receptor kinase, as well asJAK2 and TYK2 kinases, which implicated the role of this PTP incell growth control, and cell response to interferon stimulation.
Background Reference 1:
Stuible, M., et al. Trends Cell Biol. 20(11):672-679(2010)
Background Reference 2:
Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)
Background Reference 3:
Pradhan, S., et al. J. Biol. Chem. 285(38):29059-29068(2010)
Background Reference 4:
Brasil, A.S., et al. Genet Test Mol Biomarkers 14(3):425-432(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-913

List Size:
400 ul

List Price:

$495.00

Datasheet
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