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Western blot analysis in NCI-H460 cell line lysates (35ug/lane).
Western blot analysis in NCI-H460 cell line lysates (35ug/lane).

PTPN22 Antibody

CATALOG NUMBER: 58-674

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This PTPN22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 663-691 amino acids from the C-terminal region of human PTPN22.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
92 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PTPN22
Additional Names:
Tyrosine-protein phosphatase non-receptor type 22, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, Lymphoid phosphatase, LyP, PEST-domain phosphatase, PEP, PTPN22, PTPN8
Protein Accession Number:
Q9Y2R2
Protein Gi Number:
20139861
Ncbi Gene Id Number:
26191
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes of member of the non-receptor class 4subfamily of the protein-tyrosine phosphatase family. The encodedprotein is a lymphoid-specific intracellular phosphatase thatassociates with the molecular adapter protein CBL and may beinvolved in regulating CBL function in the T-cell receptorsignaling pathway. Mutations in this gene may be associated with arange of autoimmune disorders including Type 1 Diabetes, rheumatoidarthritis, systemic lupus erythematosus and Graves' disease.Alternatively spliced transcript variants encoding distinctisoforms have been described.
Background Reference 1:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 2:
Andersen, M.K., et al. Diabetes Care 33(9):2062-2064(2010)
Background Reference 3:
Bianco, B., et al. Scand. J. Immunol. 72(3):256-259(2010)
Background Reference 4:
Pradhan, V., et al.Postgrad Med 56(3):239-242(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-674

List Size:
400 ul

List Price:

$495.00

Datasheet
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