PTPRC Antibody

Background:

The protein encoded by this gene is a member of theprotein tyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processesincluding cell growth, differentiation, mitotic cycle, andoncogenic transformation. This PTP contains an extracellulardomain, a single transmembrane segment and two tandemintracytoplasmic catalytic domains, and thus belongs to receptortype PTP. This gene is specifically expressed in hematopoieticcells. This PTP has been shown to be an essential regulator of T-and B-cell antigen receptor signaling. It functions through eitherdirect interaction with components of the antigen receptorcomplexes, or by activating various Src family kinases required forthe antigen receptor signaling. This PTP also suppresses JAKkinases, and thus functions as a regulator of cytokine receptorsignaling. Four alternatively spliced transcripts variants of thisgene, which encode distinct isoforms, have been reported. [providedby RefSeq].