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Western blot analysis of PTPRD in HeLa cell lysate with PTPRD antibody at 1 μg/mL.
Western blot analysis of PTPRD in HeLa cell lysate with PTPRD antibody at 1 μg/mL.
Trial Size

PTPRD Antibody

CATALOG NUMBER: 6875

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (100%)
Immunogen:
PTPRD antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human PTPRD.
The immunogen is located within the first 50 amino acids of PTPRD.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
PTPRD antibody can be used for detection of PTPRD by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Specificity:
PTPRD antibody is human specific. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. PTPRD cleavage products are often observed in vivo
Positive Control 1:
Cat. No. 1201 - HeLa Cell Lysate
Predicted Molecular Weight:
Predicted: 165, 210 kDa (130 kDa for cleavage product)
Observed: 130 kDa
Purification:
PTPRD Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
PTPRD Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
PTPRD antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PTPRD
Additional Names:
PTPRD Antibody: HPTP, PTPD, HPTPD, HPTPDELTA, RPTPDELTA, Receptor-type tyrosine-protein phosphatase delta, Protein-tyrosine phosphatase delta
Protein Accession Number:
NP_569075
Protein Gi Number:
289547551
Ncbi Gene Id Number:
5789
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
PTPRD Antibody: PTPRD (Protein tyrosine phosphatase receptor type D) is a member of the protein tyrosine phosphatase (PTP) family that plays diverse roles during development including cell growth, differentiation, mitotic cycle and oncogenic transformation. PTPRD contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. The extracellular region of PTPRD is composed of three Ig-like and eight fibronectin type III-like domains (1,3). PTPRD interacts with PPFIA1-3 and is a tumor suppressor on chromosome 9p that is involved in the development of glioblastoma multiforme (GBMs) and multiple human cancers.
Background Reference 1:
Krueger NX, Streuli M, and Saito H. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. EMBO J. 1990; 9:3241-52.
Background Reference 2:
Fischer EH, Charbonneau H and Tonks NK. Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes. Science 1991; 253:401-6.
Background Reference 3:
Pan MG, Rim C, Lu KP et al. Cloning and expression of two structurally distinct receptor-linked protein-tyrosine phosphatases generated by RNA processing from a single gene. J. Biol. Chem. 1993; 268:19284-91.
Background Reference 4:
Veeriah S, Brennan C, Meng S, et al. The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers. Proc. Natl. Acad. Sci. USA 2009; 106: 9435-40.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6875

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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