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PTRF 1 Antibody

CATALOG NUMBER: 39-859

Clonality:
Polyclonal
Tested Applications:
ELISA, IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to the C terminal region.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IHC, WB
Application Note:
ELISA, Western (immuno) blotting, Immunostaining (in testing)
Purification:
Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Concentration:
batch dependent
Ncbi Official Symbol:
PTRF
Additional Names:
2310075E07Rik, AW546441, Cavin, MGC118550, Cavin 1, CAVIN1, CGL4, FKSG13, FLJ90031, OTTMUSP00000002049, polymerase I and transcript release factor, RNA polymerase I and transcript release factor, RP23-279L23.6, TTF I interacting 12, CAVIN, cavin-1,
Protein Accession Number:
BAG60757
Protein Gi Number:
56749614
Ncbi Gene Id Number:
284119
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Cavin 1-PTRF has been shown to be an essential component of caveolae. Cavin 1-PTRF appear to be recruited to membrane domains containing PS, cholesterol and oligomerized caveolins. Binding of Cavin 1-PTRF to these domains stabilizes the membrane curvature to produce the classic flask shape of caveolae. Disassembly of Cavin 1- PTRF releases caveolar components, including caveolins into the plasma membrane. Succinctly it appears that Cavin 1-PTRF regulates caveola structure and function.
Background Reference 1:
Hill MM, Bastiani M, Luetterforst R, Kirkham M, Kirkham A, Nixon SJ, Walser P, Abankwa D, Oorschot VM, Martin S, Hancock JF, Parton RG., PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function., Cell. 2008 Jan 11;132(1):23-4

FOR RESEARCH USE ONLY

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Disclaimer:
This product is for research use only.

CATALOG NUMBER:

39-859

List Size:
0.1 mg

List Price:

$626.00

Datasheet
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