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Western blot analysis in A549 cell line lysates (35ug/lane).
Western blot analysis in A549 cell line lysates (35ug/lane).

PUS10 Antibody

CATALOG NUMBER: 60-817

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This PUS10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-78 amino acids from the N-terminal region of human PUS10.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
60 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PUS10
Additional Names:
Putative tRNA pseudouridine synthase Pus10, 5499-, Coiled-coil domain-containing protein 139, tRNA pseudouridine 55 synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase, PUS10, CCDC139, DOBI
Protein Accession Number:
Q3MIT2
Protein Gi Number:
121942830
Ncbi Gene Id Number:
150962
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Pseudouridination, the isomerization of uridine topseudouridine, is the most common posttranscriptional nucleotidemodification found in RNA and is essential for biologic functionssuch as spliceosome biogenesis. Pseudouridylate synthases, such asPUS10, catalyze pseudouridination of structural RNAs, includingtransfer, ribosomal, and splicing RNAs. These enzymes also act asRNA chaperones, facilitating the correct folding and assembly oftRNAs (McCleverty et al., 2007 [PubMed 17900615]).[supplied byOMIM].
Background Reference 1:
Dick, D.M., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :
Background Reference 2:
McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)
Background Reference 3:
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Background Reference 4:
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-817

List Size:
400 ul

List Price:

$495.00

Datasheet
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