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Western blot analysis of lysed extracts from 293 cells using Pyk2 (Ab-402).
<b>Top Image:</b> Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Pyk2 (Ab-402).<b>Bottom Image:</b> Immunofluorescence staining of methanol-fixed HeLa cells using Pyk2 (Ab-402).
Western blot analysis of lysed extracts from 293 cells using Pyk2 (Ab-402).

Pyk2 (Ab 402) Antibody

CATALOG NUMBER: 79-362

Clonality:
Polyclonal
Tested Applications:
IF, IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Pyk2 (Ab-402) antibody was raised against a peptide sequence around aa.400~404 (D-I-Y-A-E) derived from Human Pyk2.
Conjugate:
Unconjugated
Tested Applications:
IF, IHC, WB
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Specificity:
This antibody detects endogenous level of total Pyk2 protein.
Predicted Molecular Weight:
140 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
PTK2B
Additional Names:
PKB, PTK, CAKB, FAK2, PYK2, CADTK, FADK2, RAFTK, TC25, MIG5, FADK 2, Focal adhesion kinase 2, PTK2B, Proline-rich tyrosine kinase 2 RAFTK
Protein Accession Number:
NP_004094.3
Protein Gi Number:
27886584
Ncbi Gene Id Number:
2185
Background:
Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.
Background Reference 1:
Gluck SL, et al. (2004) J Clin Invest; 114 (12): 1696-1699Benzing T, et al. (2001) Proc Natl Acad Sci U S A; 98 (17): 9784-9789Tian D, et al. (2002) Mol Cell Biol; 22 (8): 2650-2662Lu Z, et al. (2001) Mol Cell Biol; 21 (12): 4016-4031Krishnan HH, et al. (2006) J Virol; 80 (3): 1167-1180

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-362

List Size:
0.1 mg

List Price:

$370.00

Datasheet
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