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Western blot of rat cortex lysate showing specific labeling of the ~27kRab3 protein.
Western blot of rat cortex lysate showing specific labeling of the ~27kRab3 protein.

Rab 3 Antibody

CATALOG NUMBER: 50-187

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Frog, Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Frog, Human, Mouse, Rat
Immunogen:
Peptide corresponding to amino acid residues from the N-terminal region of rat Rab 3, conjugated to keyhole limpet hemocyanin (KLH).
Conjugate:
Unconjugated
Tested Applications:
WB
Predicted Molecular Weight:
27
Purification:
Affinity Purified
Clonality:
Polyclonal
Physical State:
Liquid
Concentration:
batch dependent
Storage Conditions:
Rab 3 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
Ncbi Official Symbol:
Rab3a
Protein Accession Number:
P63012
Protein Gi Number:
51702793
Ncbi Gene Id Number:
25531
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Rab proteins belong to the Ras small GTPase superfamily. The GTP-binding Rab3 subfamily has 4 known isoforms: 3A, 3B, 3C, and 3D (Schluter et al., 2004). These proteins are expressed in highest concentrations in brain and endocrine tissues and involved in regulated exocytosis of hormones and neurotransmitters (Coppola et al., 2002). Specifically, Rab3’s are thought to play a key role in presynaptic vesicle trafficking and priming (Schluter et al., 2006).
Background Reference 1:
Schluter OM, Schmitz F, Jahn R, Rosenmund C, Sudhof TC (2004) A Complete Genetic Analysis of Neuronal Rab3 Function. J Neuroscience 24(29):6629-6637
Background Reference 2:
Schluter OM, Basu J, Sudhof TC, Rosenmund C (2006) Rab3 Superprimes Synaptic Vesicles for Release: Implications for Short-term Synaptic Plasticity. J Neuroscience 26(4):1239-1246
Background Reference 3:
Coppola T, Perret-Menoud V, Gattesco S, Magnin S, Pombo I, Blank U, Regazzi R (2002) The death domain of Rab3 guanine nucleotide exchange protein in GDP/GTP exchange activity in living cells. J Biochem 362 (Pt.2):273-9.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

50-187

List Size:
0.1 mL

List Price:

$540.00

Datasheet
Shipping Info

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