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Western blot analysis of RAET1E in EL4 cell lysate with RAET1E antibody at 1 μg/ml.
Immunocytochemistry of RAET1E in K562 cells with RAET1E at 2.5 μg/mL.
Western blot analysis of RAET1E in EL4 cell lysate with RAET1E antibody at 1 μg/ml.
Trial Size

RAET1E Antibody

CATALOG NUMBER: 8193

Clonality:
Polyclonal
Tested Applications:
ELISA, ICC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
RAET1E antibody was raised against an 18 amino acid peptide near the center of human RAET1E.
The immunogen is located within amino acids 160 - 210 of RAET1E.
Conjugate:
Unconjugated
Tested Applications:
ELISA, ICC, WB
Application Note:
RAET1E antibody can be used for detection of RAET1E by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunocytochemistry in human samples. All other applications and species not yet tested.
Specificity:
RAET1E antibody is human and mouse reactive. At least four isoforms of RAET1E are known to exist; this antibody will detect all four.
Positive Control 1:
Cat. No. 1287 - EL4 Cell Lysate
Positive Control 2:
Cat. No. 17-004 - K-562 Cell Slide
Predicted Molecular Weight:
Predicted: 29 kDa
Observed: 29 kDa
Purification:
RAET1E antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
RAET1E antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
RAET1E antibody can be stored at 4°C, stable for up to one year.
Ncbi Official Symbol:
RAET1E
Additional Names:
Retinoic acid early transcript 1E, NKG2D ligand 4, N2DL-4, NKG2DL42, RL-4, ULBP4, LETAL
Protein Accession Number:
NP_631904
Protein Gi Number:
21040249
Ncbi Gene Id Number:
135250
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The Retinoic acid early transcript 1E (RAET1E) belongs to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3 (1). Like the related protein RAET1G, RAET1E differs from other RAET1 proteins in that they have type I membrane-spanning sequences at their carboxy termini rather than glycosylphosphatidylinositol anchor sequences (2). RAET1E functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses (1,3).
Background Reference 1:
Radosavlijevic M, Cuillerier B, Wilson MJ, et al. A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. Genomics 2002; 79:114-23.
Background Reference 2:
Bacon L, Eagle RA, Meyer M, et al. Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D. J. Immunol. 2004; 173:1078-84.
Background Reference 3:
Letal, a tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells. Cancer Biol. Ther. 2003; 2:446-51.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

8193

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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