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The purity of rh AGER /RAGE Fc Chimera was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
The purity of rh AGER /RAGE Fc Chimera was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.

RAGE Recombinant Protein

CATALOG NUMBER: 96-019

Tested Applications:
WB
Specifications
Source Species:
HEK293 cells
Species:
Human
Source Species:
HEK293 cells
Recombinant Protein Sequence:
Ala 23 - Ala 344
Fusion Tag:
C-Fc Tag
Tested Applications:
WB
Application Note:
This recombinant protein can be used for WB. For research use only.
Predicted Molecular Weight:
60.8 kDa
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized human S100A12 at 2μg/mL (100μl/well) can bind recombinant human AGER with a linear range of 0. 032 - 20μg/ml
Purity:
>60% as determined by SDS-PAGE.
Physical State:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
AGER
Additional Names:
AGER, RAGE
Protein Accession Number:
NP_001127
Ncbi Gene Id Number:
177
Background:
Advanced glycosylation end product-specific receptor (AGER) is also known as RAGE, and is a single-pass type I membrane protein which contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. AGER is highly expressed in endothelial cells. AGER mediates interactions of advanced glycosylation end products (AGE), and also accumulates in vascular tissue in aging and at an accelerated rate in diabetes, as well as acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGER / RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.
Background Reference 1:
Fang F., et al., 2010, FASEB J. 24:1043-1055
Background Reference 2:
Jin Q., et al., 2011, PLoS ONE 6:E19375-E19375
Background Reference 3:
Xue J., et al., 2011, Structure 19:722-732

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-019

List Size:
0.1 mg

List Price:

$405.00

Out of stock

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