RASAL1 Antibody

CATALOG NUMBER: 56-440

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Mouse
Immunogen:
This RASAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-337 amino acids from the Central region of human RASAL1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
90 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
RASAL1
Additional Names:
RasGAP-activating-like protein 1, RASAL1, RASAL
Protein Accession Number:
O95294
Ncbi Gene Id Number:
8437
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene is member of the GAP1family of GTPase-activating proteins. These proteins stimulate theGTPase activity of normal RAS p21 but not its oncogeniccounterpart. Acting as a suppressor of RAS function, the proteinenhances the weak intrinsic GTPase activity of RAS proteinsresulting in the inactive GDP-bound form of RAS, thereby allowingcontrol of cellular proliferation and differentiation. Thisparticular family member contains domains which are characteristicof the GAP1 subfamily of RasGAP proteins but, in contrast to theother GAP1 family members, this protein is strongly and selectivelyexpressed in endocrine tissues. Alternatively spliced transcriptvariants that encode different isoforms have been described
Background Reference 1:
Ohta, M., et al. Gastroenterology 136(1):206-216(2009)
Background Reference 2:
Jin, H., et al. Proc. Natl. Acad. Sci. U.S.A. 104(30):12353-12358(2007)
Background Reference 3:
Liu, Q., et al. J. Cell Biol. 170(2):183-190(2005)
Background Reference 4:
Schmitt, J.M., et al. J. Biol. Chem. 277(45):43024-43032(2002)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

56-440

List Size:
400 ul

List Price:

$495.00

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