RASSF1 Antibody

CATALOG NUMBER: 59-495

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
This RASSF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-132 amino acids from the Central region of human RASSF1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
39 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
RASSF1
Additional Names:
Ras association domain-containing protein 1, RASSF1 {ECO:0000312, EMBL:AAF351282}
Protein Accession Number:
Q9NS23
Protein Gi Number:
50401686
Ncbi Gene Id Number:
11186
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a protein similar to the RAS effectorproteins. Loss or altered expression of this gene has beenassociated with the pathogenesis of a variety of cancers, whichsuggests the tumor suppressor function of this gene. Theinactivation of this gene was found to be correlated with thehypermethylation of its CpG-island promoter region. The encodedprotein was found to interact with DNA repair protein XPA. Theprotein was also shown to inhibit the accumulation of cyclin D1,and thus induce cell cycle arrest. Seven alternatively splicedtranscript variants of this gene encoding distinct isoforms havebeen reported.
Background Reference 1:
El-Kalla, M., et al. Oncogene 29(42):5729-5740(2010)
Background Reference 2:
Vardi, A., et al. In Vivo 24(4):393-400(2010)
Background Reference 3:
Kim, J.H., et al. Virchows Arch. 457(1):35-42(2010)
Background Reference 4:
Ahmed, I.A., et al. Cancer Genet. Cytogenet. 199(2):96-100(2010)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-495

List Size:
400 ul

List Price:

$495.00

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