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Western blot analysis of RASSF10 in human lung tissue lysate with RASSF10 antibody at 1 μg/mL
Immunohistochemistry of RASSF10 in human lung tissue with RASSF10 antibody at 5 μg/mL.
Western blot analysis of RASSF10 in human lung tissue lysate with RASSF10 antibody at 1 μg/mL
Trial Size

RASSF10 Antibody

CATALOG NUMBER: 6371

Clonality:
Polyclonal
Tested Applications:
ELISA, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
RASSF10 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human RASSF10.
The immunogen is located within amino acids 50 - 100 of RASSF10.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IHC-P, WB
Application Note:
RASSF10 antibody can be used for detection of RASSF10 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Specificity:
RASSF10 antibody will not cross-react with other RAS association domain-containing family members.
Positive Control 1:
Cat. No. 1302 - Human Lung Tissue Lysate
Positive Control 2:
Cat. No. 10-101 - Human Lung Tissue Slide
Purification:
RASSF10 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
RASSF10 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
RASSF10 antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
RASSF10
Additional Names:
RASSF10 Antibody: Ras association domain-containing protein 10
Protein Accession Number:
NP_001073990
Protein Gi Number:
304434798
Ncbi Gene Id Number:
644943
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
RASSF10 Antibody: RASSF10 is a member of the N-terminal Ras association domain-containing family of proteins, a family of tumor suppressor genes that are frequently epigenetically inactivated in cancer. These proteins consist of RASSF7-10 and are structurally distinct from RASSF1-6, containing the N-terminal Ras association domain but lacking the Sav/RASSF/Hippo protein interaction domains. While little is known of the function of RASSF10, it is inactivated in both childhood leukemia and gliomas. In secondary glioblastomas, RASSF10 methylation can be used as an independent prognostic associated with worst progression-free survival and overall survival.
Background Reference 1:
Sherwood V, Manbodh R, Sheppard C, et al. RASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosis. Mol. Biol. Cell 2008; 19:1772-82.
Background Reference 2:
Hesson LB, Dunwell TL, Cooper WC, et al. The novel RASSF6 and RASSF10 candidate tumor suppressor genes are frequently epigenetically inactivated in childhood leukaemias. Mol. Cancer 2009; 8:42
Background Reference 3:
Hill VK, Underhill-Day N, Krex D, et al. Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is a frequent and an early event in gliomagenesis. Oncogene 2011; 30:30:978-89

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6371

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

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