RFXANK Antibody

Background:

Major histocompatibility (MHC) class II molecules aretransmembrane proteins that have a central role in development andcontrol of the immune system. The protein encoded by this gene,along with regulatory factor X-associated protein and regulatoryfactor-5, forms a complex that binds to the X box motif of certainMHC class II gene promoters and activates their transcription. Oncebound to the promoter, this complex associates with thenon-DNA-binding factor MHC class II transactivator, which controlsthe cell type specificity and inducibility of MHC class II geneexpression. This protein contains ankyrin repeats involved inprotein-protein interactions. Mutations in this gene have beenlinked to bare lymphocyte syndrome type II, complementation groupB. Two transcript variants encoding different isoforms have beendescribed for this gene, with only one isoform showing activationactivity.