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Western blot analysis in U937 cell line lysates (35ug/lane).
Western blot analysis in U937 cell line lysates (35ug/lane).

RGS14 Antibody

CATALOG NUMBER: 58-653

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This RGS14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-251 amino acids from the Central region of human RGS14.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
61 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
RGS14
Additional Names:
Regulator of G-protein signaling 14, RGS14, RGS14
Protein Accession Number:
O43566
Ncbi Gene Id Number:
10636
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a member of the regulator of G-proteinsignaling family. This protein contains one RGS domain, twoRaf-like Ras-binding domains (RBDs), and one GoLoco domain. Theprotein attenuates the signaling activity of G-proteins by binding,through its GoLoco domain, to specific types of activated,GTP-bound G alpha subunits. Acting as a GTPase activating protein(GAP), the protein increases the rate of conversion of the GTP toGDP. This hydrolysis allows the G alpha subunits to bind Gbeta/gamma subunit heterodimers, forming inactive G-proteinheterotrimers, thereby terminating the signal. Alternatetranscriptional splice variants of this gene have been observed buthave not been thoroughly characterized.
Background Reference 1:
Wang, J., et al. Carcinogenesis 31(10):1755-1761(2010)
Background Reference 2:
Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)
Background Reference 3:
Shu, F.J., et al. Cell. Signal. 22(3):366-376(2010)
Background Reference 4:
Dowler, E.F., et al. Biomol NMR Assign 1(1):95-97(2007)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-653

List Size:
400 ul

List Price:

$495.00

Datasheet
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