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Rhesus macaque GHR, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human GH, Tag Free at 2 ug/mL (100 uL/well) can bind Rhesus macaque GHR, Fc Tag with a linear range of 0.039-0.625 ug/mL (QC tested).
Rhesus macaque GHR, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Rhesus macaque Growth Hormone R (GHR) Recombinant Protein

CATALOG NUMBER: 11-379

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Rhesus monkey
source-species:
HEK293 cells
Recombinant Protein Sequence:
Phe 19 - Tyr 264
Fusion Tag:
Fc Tag
Tested Applications:
ELISA, WB
Application Note:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 54.7 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight:
54.7 kDa
Purity:
>90% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
Tris with Glycine, Arginine and NaCl, pH7.5
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
GHR
Additional Names:
GHR,GHBP,GH receptor
Protein Accession Number:
NP_001036132.1
Ncbi Gene Id Number:
697986
Background:
Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
Background Reference 1:
Duquesnoy P., et al., 1994, EMBO J. 13:1386-1395.
Background Reference 2:
Urbanek M., et al., 1993, J. Biol. Chem. 268:19025-19032.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-379

List Size:
0.1 mg

List Price:

$577.00

Datasheet
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