RHO Antibody

CATALOG NUMBER: 58-850

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Monkey
Immunogen:
This RHO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 310-339 amino acids from the C-terminal region of human RHO.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
39 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
RHO
Additional Names:
Rhodopsin, Opsin-2, RHO, OPN2
Protein Accession Number:
P08100
Protein Gi Number:
129207
Ncbi Gene Id Number:
6010
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Retinitis pigmentosa is an inherited progressive diseasewhich is a major cause of blindness in western communities. It canbe inherited as an autosomal dominant, autosomal recessive, orX-linked recessive disorder. In the autosomal dominant form,whichcomprises about 25% of total cases, approximately 30% of familieshave mutations in the gene encoding the rod photoreceptor-specificprotein rhodopsin. This is the transmembrane protein which, whenphotoexcited, initiates the visual transduction cascade. Defects inthis gene are also one of the causes of congenital stationary nightblindness.
Background Reference 1:
Clark, G.R., et al. Ophthalmology 117(11):2169-2177(2010)
Background Reference 2:
Li, S., et al. Biochem. Biophys. Res. Commun. 401(1):42-47(2010)
Background Reference 3:
Pulagam, L.P., et al. J. Biol. Chem. 285(38):29446-29456(2010)
Background Reference 4:
Audo, I., et al. Arch. Ophthalmol. 128(8):1036-1045(2010)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-850

List Size:
400 ul

List Price:

$495.00

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