RIPK3 Antibody

CATALOG NUMBER: 57-813

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This RIPK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 480-509 amino acids from the C-terminal region of human RIPK3.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:500
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
57 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
RIPK3
Additional Names:
Receptor-interacting serine/threonine-protein kinase 3, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3, RIPK3, RIP3
Protein Accession Number:
Q9Y572
Protein Gi Number:
205371831
Ncbi Gene Id Number:
11035
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The product of this gene is a member of thereceptor-interacting protein (RIP) family of serine/threonineprotein kinases, and contains a C-terminal domain unique from otherRIP family members. The encoded protein is predominantly localizedto the cytoplasm, and can undergo nucleocytoplasmic shuttlingdependent on novel nuclear localization and export signals. It is acomponent of the tumor necrosis factor (TNF) receptor-I signalingcomplex, and can induce apoptosis and weakly activate the NF-kappaBtranscription factor.
Background Reference 1:
Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :
Background Reference 2:
Vandenabeele, P., et al. Sci Signal(115), RE4 (2010) :
Background Reference 3:
Cho, Y.S., et al. Cell 137(6):1112-1123(2009)
Background Reference 4:
He, S., et al. Cell 137(6):1100-1111(2009)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-813

List Size:
400 ul

List Price:

$495.00

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