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Western blot analysis of RNASET2 in SW480 cell lysate with RNASET2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Immunocytochemistry of RNASET2 in SW480 cells with RNASET2 antibody at 2.5 μg/ml.
Immunofluorescence of RNASET2 in SW480 cells with RNASET2 antibody at 5 μg/ml.
Western blot analysis of RNASET2 in SW480 cell lysate with RNASET2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Trial Size

RNASET2 Antibody

CATALOG NUMBER: 6763

Clonality:
Polyclonal
Tested Applications:
ELISA, ICC, IF, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Pig: (100%)
Immunogen:
RNASET2 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human RNASET2.
The immunogen is located within the last 50 amino acids of RNASET2.
Conjugate:
Unconjugated
Tested Applications:
ELISA, ICC, IF, WB
Application Note:
RNASET2 antibody can be used for detection of FOXRED2 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1221 - SW480 Cell Lysate
Purification:
RNASET2 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
RNASET2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
RNASET2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
RNASET2
Additional Names:
RNASET2 Antibody: RNASE6PL, bA514O12.3, RNASE6PL, Ribonuclease T2, Ribonuclease 6
Protein Accession Number:
NP_003721
Protein Gi Number:
5231228
Ncbi Gene Id Number:
8635
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
RNASET2 Antibody: RNASET2 is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement, and has been suggested to function as a tumor suppressor protein. Its expression is suppressed in Human T-cell Leukemia Virus type 1 (HTLV-1) infected cells following the binding of the HTLV-1 Tax protein to the RNASET2 promoter. As Adult T-cell leukemia (ATL) is one of the primary diseases caused by HTLV-1 infection, a reduction in the level of RNASET2 by Tax may play a role in ATL development.
Background Reference 1:
Acquati F, Morelli C, Cinquetti R, et al. Cloning and characterization of a senescence inducing and class II tumor suppressor gene in ovarian carcinoma at chromosome region 6q27. Oncogene 2001; 20:980-8.
Background Reference 2:
Campomenosi P, Salis S, Lingqvist C, et al. Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins. Arch. Biochm. Biophys. 2006; 449:17-26
Background Reference 3:
Polakowski N, Han H, and Lemasson I. Direct inhibition of RNase T2 expression by the HLTV-1 viral protein Tax. Viruses 2011; 3:1485-500.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6763

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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