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Western blot analysis in MDA-MB453 cell line lysates (35ug/lane).
Western blot analysis in MDA-MB453 cell line lysates (35ug/lane).

RNF128 Antibody

CATALOG NUMBER: 60-487

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This RNF128 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the Central region of human RNF128.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
47 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
RNF128
Additional Names:
E3 ubiquitin-protein ligase RNF128, 632-, Gene related to anergy in lymphocytes protein, GRAIL, RING finger protein 128, RNF128
Protein Accession Number:
Q8TEB7
Protein Gi Number:
74751443
Ncbi Gene Id Number:
79589
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene is a type I transmembraneprotein that localizes to the endocytic pathway. This proteincontains a RING zinc-finger motif and has been shown to possess E3ubiquitin ligase activity. Expression of this gene in retrovirallytransduced T cell hybridoma significantly inhibitsactivation-induced IL2 and IL4 cytokine production. Inducedexpression of this gene was observed in anergic CD4(+) T cells,which suggested a role in the induction of anergic phenotype.Alternatively spliced transcript variants encoding distinctisoforms have been reported.
Background Reference 1:
Su, L.L., et al. J. Immunol. 183(1):438-444(2009)
Background Reference 2:
Lin, J.T., et al. J. Immunol. 182(10):5919-5928(2009)
Background Reference 3:
Lineberry, N., et al. J. Biol. Chem. 283(42):28497-28505(2008)
Background Reference 4:
Egawa, S., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 295 (1), G163-G169 (2008) :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-487

List Size:
400 ul

List Price:

$495.00

Datasheet
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