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Western blot analysis in Hela cell line lysates (35ug/lane).
Western blot analysis in Hela cell line lysates (35ug/lane).

RNF34 Antibody

CATALOG NUMBER: 58-611

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Immunogen:
This RNF34 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-311 amino acids from the C-terminal region of human RNF34.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
42 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
RNF34
Additional Names:
E3 ubiquitin-protein ligase RNF34, 632- {ECO:0000269, PubMed:25012219, ECO:0000269, Ref13}, Caspase regulator CARP1, Caspases-8 and -10-associated RING finger protein 1, CARP-1, FYVE-RING finger protein Momo, RNF34 (HGNC:17297)
Protein Accession Number:
Q969K3
Protein Gi Number:
74760679
Ncbi Gene Id Number:
80196
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene contains a RINF finger, amotif known to be involved in protein-protein and protein-DNAinteractions. This protein interacts with DNAJA3/hTid-1, which is aDnaJ protein reported to function as a modulator of apoptosis.Overexpression of this gene in Hela cells was shown to confer theresistance to TNF-alpha induced apoptosis, suggesting ananti-apoptotic function of this protein. This protein can becleaved by caspase-3 during the induction of apoptosis.Alternatively spliced transcript variants encoding distinctisoforms have been reported.
Background Reference 1:
Erlbruch, A., et al. Proteomics 10(16):2890-2900(2010)
Background Reference 2:
Yang, W., et al. Cell Cycle 7(5):670-682(2008)
Background Reference 3:
Yang, W., et al. J. Biol. Chem. 282(5):3273-3281(2007)
Background Reference 4:
Konishi, T., et al. Mol. Cancer Ther. 4(5):743-750(2005)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-611

List Size:
400 ul

List Price:

$495.00

Datasheet
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